ZFIN Image: Tanaka et al., 2017, Fig. 8

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Figure Caption

Fig. 8

Activation of the FGF signaling pathway maintains dkk1b expression levels from mid-gastrulation to early somitogenesis, whereas chd fails to maintain dkk1b expression levels after mid-gastrula stage. Expression of dkk1b in (A–C) wild-type embryos, (D–F, P and Q) uninjected ichabod embryos, (G–I) FGF8 mRNA-injected ichabod embryos, (J–L) chd mRNA-injected ichabod embryos, (M–O, R and S) β-catenin mRNA-injected ichabod embryos, (T and U) β-catenin and XFD mRNA-injected ichabod embryos, and (V and W) β-catenin and d50 mRNA-injected ichabod embryos. Embryos are shown at the shield stage (P, R, T and V, dorsal views), 65% epiboly (A, D, G, J, M, Q, S, U and W, dorsal views), 90% epiboly (B, E, H, K and N, animal views), and 5-somite stage (C, F, I, L and O, lateral views). Scale bars represent 100 µm.

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Acknowledgments

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Reprinted from Developmental Biology, 424(2), Tanaka, S., Hosokawa, H., Weinberg, E.S., Maegawa, S., Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish, 189-197, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.