ZFIN Image: Venero Galanternik M. et al., 2016, Fig. 3

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Figure Caption

Fig. 3

glypican4 acts redundantly with other HSPGs in the primordium. (A-B′) Lateral views of sibling (A) and glypican4^fr6 mutant (B) embryos stained for the Wnt/β-catenin target lef1. (A-B) Sibling and glypican4^fr6 mutant embryos show normal expression of lef1 restricted to the leading region of the primordium. (A′-B′) show magnifications of the primordia in (A-B). (C-E′) Lateral views of a sibling (C), a glypican4^+/fr6 heterozygous (D) and a homozygous glypican4^fr6 mutant (E) treated with a suboptimal dose of Sodium Chlorate (100 mM) and stained for lef1. The treatment does not affect expression of lef1 in wild type primordia (C′) but lef1 expression expands in both heterozygous glypican4^+/fr6 and homozygous glypican4^fr6 mutants (D′ and E′).

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Acknowledgments

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Reprinted from Developmental Biology, 419(2), Venero Galanternik M., Lush, M.E., Piotrowski, T., Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously, 321-335, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.