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Fig. S9
Depletion of Rbfox1l or Rbfox2 alone does not alter the striated appearance of myofibrils. Phalloidin labeling of thin filaments in skeletal muscle of WT embryos reveals normally striated fibers in both fast and slow muscle (A-B). Fiber arrangment of rbfox1l morphants was mildly affected at doses of 9 ng (C-D), whereas rbfox2 morphant fibers had a normal appearance (E-F). In contrast, halved doses of 4.5 ng each of rbfox1l and rbfox2 sbMOs, when co-injected, resulted in highly disorganized, wavy fibers (G-H). Scale bar = 50 µm.
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Reprinted from Developmental Biology, 359(2), Gallagher, T.L., Arribere, J.A., Geurts, P.A., Exner, C.R., McDonald, K.L., Dill, K.K., Marr, H.L., Adkar, S.S., Garnett, A.T., Amacher, S.L., and Conboy, J.G., Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions, 251-61, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.