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Fig. 10
Chondrocyte differentiation is particularly sensitive to disruption of Hh signaling. All panels are anterior to the left. (A-B, A′-B′) At 10 h post-fertilization (hpf), the early mesoderm marker has2 is expressed in the anterior region of smoothened mutants and wildtypes (Compare B to A, B′ to A′). (C and D) However, smoothened mutants display a marked reduction in col2a1a expression in the forming postchordal neurocranium at 28 hpf compared to siblings (compare D to C, arrowhead denotes anterior notochord). Scale bar=50 µm in A and 10 µm in A′.
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Reprinted from Developmental Biology, 415(2), McCarthy, N., Sidik, A., Bertrand, J.Y., Eberhart, J.K., An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull, 261-77, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.