ZFIN Image: McCarthy et al., 2016, Fig. S11

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Figure Caption

Fig. S11

SU5402 treatment reduces the expression of col2a1a and sox9a in fgf8a mutants at 24 hpf. (A-D) col2a1a and (E-H) sox9a in situ hybridization at 24 hpf. Arrowheads denote anterior tip of notochord. Expression of col2a1a is observed abutting and along the notochord of (A) DMSO-treated wildtype (B) DMSO-treated fgf8a mutants, and (C) SU5402-treated wildtype. However, (D) SU5402-treated fgf8a mutants show a marked reduction in col2a1a expression. Expression of sox9a is observed abutting the notochord of (E) DMSO-treated wildtype (F) DMSO-treated fgf8a mutants, and (G) SU5402-treated wildtype. However, (H) SU5402-treated fgf8a mutants show reduced expression of sox9a. Dorsal view with anterior to the left. scale bar=20 µm.

Acknowledgments

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Reprinted from Developmental Biology, 415(2), McCarthy, N., Sidik, A., Bertrand, J.Y., Eberhart, J.K., An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull, 261-77, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.