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Fig. 7
Maxillary CNCC fail to condense properly in pdgfra-/-;pdgfrb-/- embryos beginning at 24 hpf. A-C′′′: Stills of confocal movies of pdgfra+/+;pdgfrb+/+, pdgfra-/-;pdgfrb+/+, and pdgfra-/-;pdgfrb-/- embryos, respectively. Anterior is to the left. Arrowheads point to the anterior most maxillary domain. In a pdgfra-/-;pdgfrb+/+ embryo (B-B′′′), the maxillary CNCC condensation progress anteriorly throughout craniofacial morphogenesis, while in pdgfra-/-;pdgfrb-/- embryo (C-C′′′), maxillary domain CNCC fails to extend, compared with pdgfra+/+;pdgfrb+/+ (A-A′′′). Scale bar = 50 µm.
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