ZFIN Image: Berg et al., 2016, Fig. 5

Image

Figure Caption

Fig. 5

Lysosomal Storage Disorders Disrupt Macrophage Migration and Cause Granuloma Breakdown

(A and B) Confocal images of green fluorescent macrophages in the brain of 3-dpf control and morphant larvae, unstained (A) or following staining with LysoTracker Red (B). Scale bars, 10 µm.

(C) Quantification of average macrophage speed in control and morphant larvae by macrophage morphology (wt, wild-type; vac, vacuolated).

(D-F) Quantification of bacterial cording in control and morphant larvae at 3 dpi with 200 Mm. Statistical significance was determined using paired t tests with Bonferroni correction (C) and Fisher’s exact test (D-F).

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Acknowledgments

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Reprinted from Cell, 165, Berg, R.D., Levitte, S., O'Sullivan, M.P., O'Leary, S.M., Cambier, C.J., Cameron, J., Takaki, K.K., Moens, C.B., Tobin, D.M., Keane, J., Ramakrishnan, L., Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration, 139-152, Copyright (2016) with permission from Elsevier. Full text @ Cell