ZFIN Image: Voelz et al., 2015, Fig. 5

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Fig. 5

A zebrafish larval swim bladder infection model for mucormycosis. (A) AB wild-type zebrafish larvae were injected in the swim bladder 4days post-fertilization (d.p.f.) with a LD or a HD of M. circinelloides NRRL3631. (B) No significant mortality was observed after mucormycete spore injection into the swim bladder 4d.p.f. (PVP versus LD Mc P=0.172; PVP versus HD Mc P=0.403; LD Mc versus HD Mc P=0.561; n=68). (C) Spores remained viable within the zebrafish larvae over the time course of 48h.p.i. (D,E) Macrophages and neutrophils are recruited to the site of infection after injection of viable spores into the swim bladder. Injection of UV-killed spores did not induce significant phagocyte recruitment. (F,G) No significant induction of the pro-inflammatory cytokines il1b or tnfα was detected at 6 or 24h.p.i. with the exception of weak tnfα induction at 24h.p.i.

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Acknowledgments

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