ZFIN Image: Antonio et al., 2015, Fig. 4

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Figure Caption

Fig. 4

PGE₂ is one component of the trophic signal driving woundinflammationtriggered preneoplastic cell proliferation

A–B′ Images of Ras⁺ larval flanks from control fish bathed in Danieau′s solution or with 10 µM NS398 to block Cox2 enzyme activity, and left unwounded (A, B) or laserwounded (A′, B′) at 3 dpf before subsequent fixation at 5 dpf.

C. Graph showing quantification of preneoplastic cell numbers at 5 dpf from (A–B′) (n = 15–20 larvae in each group).

D, D′ Unwounded control Ras⁺ larvae (D) versus sibling larvae that have been laserwounded at 2 dpf (D′).

E–F′ Unwounded versus wounded larvae after injection with PU1 and GCSF morpholinos (E and E′), and addition of 20 µM dmPGE₂ (F and F′).

G. Graph showing preneoplastic cell numbers from (D–F′).

Figure Data

Expression / Labeling details

Acknowledgments

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