Image
|
Figure Caption
Fig. 5
Cyp26a1 is required for increased cardiac specification in VP-RAR expressing embryos. (A?D) ISH of nkx2.5 in embryos obtained from a gir+/- adult cross with and without vp-rar mRNA injection. nkx2.5 expression is increased in vp-rar mRNA injected gir+/? embryos compared to their uninjected siblings, while vp-rar mRNA injected gir-/- embryos show no difference compared to uninjected gir-/- siblings. (E) Quantification of nkx2.5 expression length. Asterisks indicate statistically different from control (p<0.05) using Student′s t-test.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Reprinted from Developmental Biology, 405(1), Rydeen, A., Voisin, N., D'Aniello, E., Ravisankar, P., Devignes, C.S., Waxman, J.S., Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling, 47-55, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.