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Figure Caption
Fig. 8 hsa-SMN1 rescues the dre-smn1 knockdown motor neuron phenotype.
Representative images of 52hpf zebrafish larvae expressing GFP in motor neurons. Lateral views of (a) control (empty vector) transgenic animals. (b–d) transgenic UBI:miRsmn1-1#5 zebrafish line (presenting ~90% downregulation of SMN), with hsa-SMN1 RNA injection (c) or hsa-SMN1 ubiquitous expression via integrated transgene (d; see Supplementary Fig. 7 for strategy used). Scale bar, 50µm.
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