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Fig. 5 Representative images of 52 hpf zebrafish larvae expressing GFP in motor neurons ± smn1 knockdown.
Lateral views of (a) control (empty vector) and (b-e) transgenic zebrafish larvae expressing artificial miR (targeting smn1 3′-UTR). Compared with control animals, transgenic larvae expressing miRsmn1 present abnormal motor neuron development, including abnormal branching, short axons as well as pathfinding errors (white arrowheads). Transgenic animals expressing artificial miRNA against the ORF (targets 2 and 3) do not show obvious motor neuron abnormality. Scale bar, 50µm.
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Full text @ Nat. Commun.