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Fig. 6
The Tg(hsp70l:dnfgfr1-EGFP) transgenic line provides a temporal model for loss of vsx2. Immunohistochemistry was performed on retinal sections of Dnfgfr1- no heat shock, Dnfgfr1-heat shock, Dnfgfr1+MO1a-no heat shock, and Dnfgfr1+MO1a-heat shock at 48 hpf. The markers used are Vsx2 (A–D) and Zn5 (E–H). Vsx2 expression was not completely rescued when both dmbx1 and FGF signaling was knocked down but differentiation of Zn5 positive ganglion cells was partially rescued.
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Reprinted from Developmental Biology, 402(2), Wong, L., Power, N., Miles, A., Tropepe, V., Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression, 216-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.