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Fig. 7
Neurod knockdown increases production of secondary endocrine precursor cells. Confocal images (merged z-stacks) of representative 6 dpf Tg(neurod:EGFP) Control (A, C, E, G) and Neurod ATG morphant (B, D, F, H) specimens. Whole mount immunolabeling for insulin (C, D), glucagon (E, F) and GFP (G, H). (I) Mean (±s.d.) number of cells expressing insulin, glucagon, GFP-positive secondary endocrine cells from 6 independent experiments and from a minimum of 20 larvae per group. *P<0.0001; t-test, two-tailed distribution. Secondary endocrine precursor cells; arrowhead. Scale bar=20 µm.
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Reprinted from Developmental Biology, 402(1), Dalgin, G., Prince, V.E., Differential levels of Neurod establish zebrafish endocrine pancreas cell fates, 81-97, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.