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Fig. S3
Dorsal bud endocrine cell types display differential sensitivity to Neurod knockdown. In situ hybridization for glucagon (gcga, A-D), insulin (insa, F-I), somatostatin2 (sst2, K-N) and aristaless related homeobox a (arxa, P-S) at 30 hpf. Control (A, F, K, P), Neurod UTR MO 2 ng (B, G, L, Q), 4 ng (C, H, M, R) or 8 ng (D, I, N, S) injected specimens. Mean (± s.d.) number of cells expressing gcga (E), insa (J), sst2 (O) and arxa (T) from four independent experiments and from a minimum of 20 embryos per group. Arrowheads indicate dorsal bud endocrine cells.
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Reprinted from Developmental Biology, 402(1), Dalgin, G., Prince, V.E., Differential levels of Neurod establish zebrafish endocrine pancreas cell fates, 81-97, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.