ZFIN Image: Glenn et al., 2014, Fig. 3

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Fig. 3

etv2 functions cell autonomously in neutropoiesis. Donor mpx:GFP embryos were injected with either TRITC-dextran tracer or TRITC-dextran and etv2 DNA, and the cells were transplanted at the sphere stage (4 hpf) into mpx:GFP recipient embryos. (A–C) Wild type cells transplanted into a wild type host do not induce mpx expression. (A) mpx:GFP, (B) TRITC and (C) merged fluorescence in the recipient embryos at 26 hpf stage. (D–F) A subset of etv2-overexpressing cells transplanted into a wild type host induce mpx expression autonomously. (D) mpx:GFP, (E) TRITC and (F) merged fluorescence in the recipient embryos at 26 hpf stage. White arrowheads point to overlapping cells, indicating that they are derived from the donor etv2-overexpressing embryos.

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Acknowledgments

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Reprinted from Developmental Biology, 393(1), Glenn, N.O., Schumacher, J.A., Kim, H.J., Zhao, E.J., Skerniskyte, J., Sumanas, S., Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish, 149-59, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.