ZFIN Image: Lush et al., 2014, Fig. 4, S2

Image

Figure Caption

Fig. 4, S2

wnt10a, fgf3 and fgf10 expression depends on Wnt/β-catenin signaling.

Control or Tg(sox10:DNerbb4) siblings were treated with DMSO, IWR-1, PD173074 or LY411575 at 32 hpf then fixed at 48 hpf for in situ hybridizations. In control siblings, inhibitor treatment has no effect on wnt10a (A–D), fgf3 (I–L) or fgf10 (Q–T) expression in interneuromast cells. wnt10a is strongly induced in Tg(sox10:DNerbb4) DMSO (E), PD173074 (G) or LY411575 (H) treated embryos but is greatly inhibited in IWR-1 treated embryos (F). Likewise, IWR-1 inhibits fgf3 (N) and fgf10 (V) expression in Tg(sox10:DNerbb4). Neither PD173074 or LY411575 effect fgf3 (O–P) or fgf10 expression (W–X) in Tg(sox10:DNerbb4).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife