ZFIN ID: ZDB-PUB-140513-325
ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/beta-catenin
Lush, M.E., Piotrowski, T.
Date: 2014
Source: eLIFE   3: e01832 (Journal)
Registered Authors: Lush, Mark E., Piotrowski, Tatjana
Keywords: glia, neuromast, stem cells
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Cell Communication*/drug effects
  • Cell Differentiation
  • Cell Proliferation
  • Fibroblast Growth Factors/metabolism
  • Gene Expression Regulation, Developmental
  • Genotype
  • Lateral Line System/cytology
  • Lateral Line System/drug effects
  • Lateral Line System/metabolism*
  • Mutation
  • Neural Stem Cells/drug effects
  • Neural Stem Cells/metabolism*
  • Neuregulins/metabolism
  • Phenotype
  • Protein Kinase Inhibitors/pharmacology
  • Receptors, Notch/metabolism
  • Schwann Cells/drug effects
  • Schwann Cells/metabolism*
  • Stem Cell Niche
  • Time Factors
  • Wnt Signaling Pathway*/drug effects
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • beta Catenin/genetics
  • beta Catenin/metabolism*
PubMed: 24642408 Full text @ Elife
Proper orchestration of quiescence and activation of progenitor cells is crucial during embryonic development and adult homeostasis. We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to understand how integration of diverse signaling pathways spatially and temporally regulates the coordination of these processes. Our previous studies demonstrated that Schwann cells play a crucial role in negatively regulating lateral line progenitor proliferation. Here we demonstrate that ErbB/Neuregulin signaling is not only required for Schwann cell migration but that it plays a continued role in postmigratory Schwann cells. ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiation through non-cell-autonomous inhibition of Wnt/β-catenin signaling. Subsequent activation of Fgf signaling controls sensory organ differentiation, but not progenitor proliferation. In addition to the lateral line, these findings have important implications for understanding how niche-progenitor cells segregate interactions during development, and how they may go wrong in disease states.