ZFIN Image: Lush et al., 2014, Fig. 1, S3

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Figure Caption

Fig. 1, S3

nrg1-3z26 mutants lose neuromasts as they age.

Control sibling Tg(SqET20:gfp) (A) or nrg1-3^z26/Tg(SqET20:gfp) (B), were imaged at 1 month of age. Neuromasts that stay along the midline can be seen in control siblings (A, arrowhead). These neuromasts are lost from the more posterior region in nrg1-3^z26 adult zebrafish (B, arrowhead). Similarly neuromasts are also lost from the more ventral lateral line (arrows), which are mostly derived from primI, in nrg1-3^z26 (B). (C–D2) At 4 months of age the degeneration of neuromasts is even more severe. In controls at four months multiple stitches of neuromasts can be seen after DASPEI staining along the ventral line (C) and tail fin (C2). nrg1-3^z26 have no ventral lateral line (D) or tail fin (D2) neuromasts remaining at 4 months.

Acknowledgments

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