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Fig. S5
Immunostaining with ZL-1 (red) and in situ hybridization with pax6b, pax2.1 and foxe3 antisense riboprobes in wild-type (A-F), mab21l2Q48Sfs*5 (A1-F1) andmab21l2R51_F52del (C2-F2) embryos.
The ZL-1 staining is absent in 24-hpf (A1) but present in 48–72-hpf mutant embryos (B1, C1, C2), pax2.1 pattern is abnormal in 72-hpf mutant embryos (D1, E1, D2, E2), arrowhead in D1 shows abnormal areas of pax2.1-positive cells in the central retina and arrowheads in E1 show broad and intense expression in the region of optic fissure; foxe3 expression is decreased in 48-hpf mutants (F1, F2); le, lens; of, optic fissure.
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