ZFIN Image: Delaurier et al., 2014, Fig. 4

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Figure Caption

Fig. 4

Loss of mef2ca results in the ectopic differentiation of cells with Op joint identity. Confocal projections of larvae expressing trps1:EGFP at 6 dpf, live imaged after counterstaining vitally with Alizarin Red. (A) Wild-type cells of the Op-hyosymplectic articulation, but not BR-ceratohyal cartilage articulation, express high levels of trps1:EGFP (arrow). (B) Mutant cells of the expanded (transformed) BR-ceratohyal articulation now show high levels of trps1:EGFP (arrow). (C) A region of ectopic bone cells not involving the BR, express high levels of trps1:EGFP (arrow). A stunted bony spur at the position of the BR does not show high expression (asterisk). (D) A mutant showing less ectopic bone expansion matches the wild type (A) in trps1:EGFP expression. Scale bar 50 μm.

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Acknowledgments

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Reprinted from Developmental Biology, 385(2), Delaurier, A., Huycke, T.R., Nichols, J.T., Swartz, M.E., Larsen, A., Walker, C., Dowd, J., Pan, L., Moens, C.B., and Kimmel, C.B., Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton, 189-99, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.