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Fig. 4
Loss of Tmem88a results in profound cardiomyopathy. (A) Brightfield images of representative control (MOCtrl) and tmem88a (MOT88a) morphants at 48 hpf. Arrowhead indicates pericardial edema. (B,C) Higher magnification of craniocardiac tissues in control and tmem88a morphants. Brain (br), eye (e), yolk (y), heart (hrt, arrowheads) and blood (bl, arrow) are indicated. (D,E) Fluorescent images of control and tmem88a morphant hearts observed in the tg(myl7:eGFP) background. Ventricle (v) and atrium (a) are indicated. n>50 embryos analyzed per panel. Scale bars: 0.1 mm in B-E.
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