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Fig. 9
Notch-Delta and Her4 negatively regulate insm1a expression. (A, B) Pharmacologic inhibition of Notch signaling with DAPT resulted in an upregulation of insm1a expression in the developing eye and brain (B), compared to control (DMSO) treated embryos (A). (C) Co-transfection of HEK293 cells with a her4 cDNA expression vector repressed a luciferase reporter gene driven by either 300 bp (left) or 2.5 kb (right) of the insm1a promoter. D, dorsal; V, ventral; A, anterior; P, posterior; L, lens; hpf, hours post fertilization.
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Reprinted from Developmental Biology, 380(2), Forbes-Osborne, M.A., Wilson, S.G., and Morris, A.C., Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina, 157-171, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.