Gene
insm1a
- ID
- ZDB-GENE-040426-1810
- Name
- insulinoma-associated 1a
- Symbol
- insm1a Nomenclature History
- Previous Names
-
- zgc:77257
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including sensory epithelium regeneration; sensory system development; and spinal cord motor neuron differentiation. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; optic cup; pancreas primordium; presumptive telencephalon; and trigeminal placode. Orthologous to human INSM1 (INSM transcriptional repressor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-insm1a | (4) | |
| MO1-insm1a | N/A | (2) |
| MO2-insm1a | N/A | Ramachandran et al., 2012 |
| MO3-insm1a | N/A | Forbes-Osborne et al., 2013 |
| MO4-insm1a | N/A | Forbes-Osborne et al., 2013 |
| MO5-insm1a | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulinoma-associated protein 1/2 | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q6P0F9 | InterPro | 383 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
insm1a-201
(1)
|
Ensembl | 2,430 nt | ||
| mRNA |
insm1a-202
(1)
|
Ensembl | 1,190 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(insm1a:EGFP) |
|
| 1 | Gong et al., 2017 | |
| Tg(insm1a:mCherry) |
|
| 1 | Gong et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-223E1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77257 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205644 (1) | 2434 nt | ||
| Genomic | GenBank:CU694316 (2) | 38368 nt | ||
| Polypeptide | UniProtKB:Q6P0F9 (1) | 383 aa |
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Wang, J., Chai, R., Fang, X., Gu, J., Xu, W., Chen, Q., Chen, G., Zhu, S., Jin, Y. (2022) In Situ Hybridization Combined with Immunohistochemistry in Cryosectioned Zebrafish Embryos. Journal of visualized experiments : JoVE. (181):
- Xing, L., Chai, R., Wang, J., Lin, J., Li, H., Wang, Y., Lai, B., Sun, J., Chen, G. (2022) Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. The Journal of biological chemistry. 298(10):102452
- Zhao, G., Hu, J., Gao, M., Zhu, Y., Hong, Y. (2022) Excessive selenium affects neural development and locomotor behavior of zebrafish embryos. Ecotoxicology and environmental safety. 238:113611
- Kent, M.R., Kara, N., Patton, J.G. (2021) Inhibition of GABAA-ρ receptors induces retina regeneration in zebrafish. Neural regeneration research. 16:367-374
- Yang, L., Webb, S.E., Jin, N., Lee, H.M., Chan, T.F., Xu, G., Chan, J.C.N., Miller, A.L., Ma, R.C.W. (2021) Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Journal of diabetes investigation. 12(5):710-727
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Lu, J., Liu, R., Miao, A., Chen, X., Xiao, W., Wang, Y., Cao, D., Pan, J., Li, L., Luo, Y. (2020) The role of cldnh during the early retinal development in zebrafish. Experimental Eye Research. 200:108207
- Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Saran, N.K., Ramachandran, R. (2020) Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 23:100817
- Wang, M., Du, L., Lee, A.C., Li, Y., Qin, H., He, J. (2020) Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes. The Journal of cell biology. 219(9):
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