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Fig. 2 Akt1 knockdown using specific morpholinos is sufficient to cause developmental abnormalities in a dose-dependent manner.
Representative images of morpholino-injected embryos. The following doses were used for microinjection: low dose, 6 ng MO1 or 1 ng MO2; medium dose, 10 ng MO1 or 2 ng MO2; high dose, 14 ng MO1 or 4 ng MO2. Arrowheads denote bent body characteristics, while arrows indicate edema in the pericardial sac. Brain malformations are marked by asterisks. These morphological phenotypes were rescued by concomitant injection with 1 ng akt1 mRNA, as shown in the right panels.
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Full text @ PLoS One