ZFIN Image: Torregroza et al., 2012, Fig. 8

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Figure Caption

Fig. 8 Expression of dominant-negative SR-Gata4 during gastrulation causes a block in development of the CHT plexus.

Shown are representative transgenic embryos that were either left at normal temperature (A) or heat shocked for one hour at 37C starting at 3.5 hpf. Embryos are derived from crossing the tg(sr-gata4) line with the tg(fli:egfp) reporter strain. Those embryos carrying the transgene expressing SR-Gata4 are identified by RFP+ hearts (not shown here). Insets show magnified view of the equivalent regions of the developing CHT at 48 hpf. The normal fenestrated structures (an example indicated by the asterisk in A) were seen in 85% of the non-heat-shocked embryos, while in contrast, 84% of the heat-shocked embryos lacked these angiogenic structures. For each, n>50.

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Acknowledgments

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