ZFIN Image: Freitas et al., 2012, Fig. S1

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Figure Caption

Fig. S1 Control experiments for the hoxd13a and hoxa4a dexamethasone (Dex)-inducible injected constructs. All panels show embryos at 4 dpf. A-B, Wild type embryos (wt) treated with Dex 32 hpf (A) and embryos injected with hoxd13a-GR but not treated with Dex (B) did not show any phenotypic alteration. C-D, Control embryos injected with hoxa4a-GR, did not present phenotypic alterations either when they were exposed (C) or not (D) to Dex at 32 hpf. E-F, Deformation of the body axis was observed in 18% (n=50) of sibling embryos injected with hoxa4a-GR and treated with Dex at 50% of epiboly (E) but no abnormalities were detected in fins (yellow arrows, F).

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Reprinted from Developmental Cell, 23(6), Freitas, R., G�mez-Mar�n, C., Wilson, J.M., Casares, F., and G�mez-Skarmeta, J.L., Hoxd13 contribution to the evolution of vertebrate appendages, 1219-1229, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell