ZFIN Image: Lane et al., 2012, Fig. 2

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Figure Caption

Fig. 2 Otx morphant phenotypes.

(A–C) Eye phenotypes, assessed at 5 dpf, were scored as normal when the RPE displayed no visible defects (A), minor when coloboma was present but anterior and posterior ventral RPE were still contiguous (B), and major when the anterior and posterior ventral RPE were completely separated (C). (D) Histogram showing the eye defects induced by otx gene knockdown when injected at a morpholino concentration of 1.25 ng/embryo. Knockdown of individual otx genes caused only minor defects, while knockdown of otx1a and otx2 together, or all three otx genes together, produced a majority of embryos with major eye defects. otx1a, N = 108; otx1b, N = 230; otx2, N = 122; otx1a/otx1b, N = 222; otx1b/otx2, N = 256; otx1a/otx2, N = 214; otx1a/otx1b/otx2, N = 178.

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Phenotype details

Acknowledgments

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