Image
|
Figure Caption
Fig. 7
Abnormal L–R molecular marker expression in Xenopus and zebrafish Zic3 morphants. (A) Pitx2 expression in Xenopus Zic3 morphant embryos at stage 30. Embryos were photographed from both left and right sides. Red arrows highlight pitx2 expression. (B) Quantitative results of pitx2 expression in non-injected control (CTRL), control morpholino (CTRL MO) and Zic3 splice site morpholino (SS MO). (C) Southpaw (spaw) expression in zebrafish Zic3 morphant embryos. Red arrows highlight gene expression as left, right, bilateral or absent. (D) Quantitative results of spaw expression in control and Zic3 morphants.
Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Reprinted from Developmental Biology, 364(1), Cast, A.E., Gao, C., Amack, J.D., and Ware, S.M., An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis, 22-31, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.