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Fig. 3
The ccm3a/b cranial vasculature phenotype is specific to ccm3 function and not due to lack of blood flow. Neither santa or valentine mutant embryos display severe vascular dilations or mispatterning seen upon morpholino mediated ccm3a/b knockdown (for san, n = 21, for vtn, n = 32) (E-H) sih embryos similarly displayed no dilations in their cranial vasculature (n = 25) (I and J). Deep confocal z-stack projections (A, C, E, G and I) or z-stacks of dorsal views of the cranial vasculature (B, D, F, H and J) are shown.
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Reprinted from Developmental Biology, 362(2), Yoruk, B., Gillers, B.S., Chi, N.C., and Scott, I.C., Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease, 121-131, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.