ZFIN Image: Langenbacher et al., 2012, Fig. 1

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Figure Caption

Fig. 1

Sodium pump function is important for cardiomyocyte migration and heart tube elongation. (A–D) Time-lapse images showing a dorsal view (anterior to top) of heart morphogenesis in a wild type Tg(myl7:EGFP) embryo. After arriving at the midline, wild type cardiomyocytes rapidly migrate anteriorly and leftward between 18.5 and 26 hpf, generating the heart tube. (E–H) Time-lapse images showing a dorsal view (anterior to top) of heart morphogenesis in a atp1a1^m883 mutant Tg(myl7:EGFP) embryo. Cardiomyocytes migrate to the midline normally in the majority of atp1a1^m883 mutants (E), but only exhibit limited migration from 18.5 to 26 hpf. At 26 hpf, atp1a1^m883 mutants have a clump of cardiomyocytes at the midline (H).

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Acknowledgments

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Reprinted from Developmental Biology, 362(2), Langenbacher, A.D., Huang, J., Chen, Y., and Chen, J.N., Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis, 263-270, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.