Fig. 1

Fig. 1 Phenotype of the zebrafish out of sight mutant. (A - B) Lateral views of wild-type zebrafish (A) and of the out^m233 mutant (B) at 36 hpf, 48 hpf (a1 and b1), 72 hpf (a2 and b2) and 96 hpf (a3 and b3). The out^m233 mutant is characterized by a severe reduction in eye size. No obvious defects are observed in other organs. (C - D) Transverse plastic sections of wild-type (C) and out^m233 mutant (D) retinae at 36 hpf, 4 dpf (c1 and d1) and 5 dpf (c2 and d2). Although the retina and lens are grossly reduced in size in out^m233 mutants, their overall architectures appear largely intact. (E - F) An anophthalmic out^m233 homozygous mutant at ca. 2 months of age. An enlargement of the head region is shown in (F). (G - H) A wild-type individual (G) and its microphthalmic out^m233 sibling (H) at 2.5 months of age. In A, B, and E-H, anterior is to the left