ZFIN Image: Kwon et al., 2010, Fig. S5

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Figure Caption

Fig. S5 Blocking Fgf and Pdgf signaling leads to downregulation of preplacodal markers. (Upper two rows) Dorsal views showing expression of eya1 and dlx3b at 11 hpf in wild-type embryos that were treated beginning at 8.5 hpf with 15µM AG1295, 25µM SU5402, or both. AG1295 did not cause any significant changes in the expression. SU5402 reduced expression of both genes. Addition of both inhibitors caused loss of eya1 within the preplacodal domain and significant downregulation of dlx3b. (Lower row) Images of live embryos at 24 hpf. Treatment with SU5402 or both SU5402 and AG1295 severely perturbed caudal development and blocked formation of the otic vesicle.

Acknowledgments

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