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Fig. 6 Bbs8 and Vangl2 are required for normal fluid flow in the Kupffer′s vesicle. A) Schematic representation of the site of bead injection into the KV for fluid flow analysis. B) Bright field image of the KV with injected beads (red circles). C-F) Tracked bead movements in live bbs8-MO injected tri embryos at 4–5-somite stages. C) A constant anti-clockwise circular movement as seen from the dorsal side was observed in WT embryos. D, E) Bead movement was disrupted in both bbs8-morphants and tri-/- mutants. F) Abrogation of both vangl2/tri and bbs8 abolishes this bead movement completely.
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Reprinted from Developmental Biology, 345(2), May-Simera, H.L., Kai, M., Hernandez, V., Osborn, D.P., Tada, M., and Beales, P.L., Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish, 215-225, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.