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Fig. 6 Pea3 ETS factors are required for ciliogenesis in the Kupffer′s vesicle and subsequent L/R patterning. (A, B) Tg(dusp6:EGFP)pt6 embryos injected with 3EtsMO show grossly normal formation of Kupffer′s vesicle, even though FGF signaling was suppressed (B, B′). (C, D) Cilia number in the KV was reduced in 3EtsMO-injected embryos at the 12-somite stage. (E) Graph showing average number of cilia in MO-injected embryos. Expression of spaw in 3EtsMO-injected embryos reveals L/R defects at 18-somite stage (F–I). (J) Graph depicting L/R defects in Pea3 ETS and Fgf8 depleted embryos.
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Reprinted from Developmental Biology, 342(1), Znosko, W.A., Yu, S., Thomas, K., Molina, G.A., Li, C., Tsang, W., Dawid, I.B., Moon, A.M., and Tsang, M., Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development, 11-25, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.