ZFIN Image: Chang et al., 2010, Fig. 4

Image

Figure Caption

Fig. 4 Foxd3 regulation of axis formation is dependent on the Nodal signaling pathway. Wild-type (WT) or MZoep mutant embryos were injected at the one-cell stage with zebrafish foxd3 (25 pg) or Xenopus ActivinΒB (25 pg) mRNA and analyzed at the 24 hpf stage (A, B, D, E, G, H) or early somitogenesis stage (11 hpf) (C, F, I). Uninjected (A, B), foxd3-injected (D, E), and Activin-injected (G, H) wild-type (A, D, G) and MZoep (B, E, H) embryos at 24 hpf are shown (lateral views of live embryos with anterior left). In situ hybridization showing notochord expression of no tail (ntl) (C, F, I) in uninjected (C), foxd3-injected (F), and Activin-injected (I) MZoep embryos at early somitogenesis stage (11 hpf) (dorsal views with anterior up).

Acknowledgments

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Reprinted from Developmental Biology, 342(1), Chang, L.L., and Kessler, D.S., Foxd3 is an Essential Nodal-Dependent Regulator of Zebrafish Dorsal Mesoderm Development, 39-50, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.