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Fig. 3 Foxd3 induction of mesoderm is dependent on an active Nodal signaling pathway. Wild-type (WT) or MZoep mutant embryos were injected at the one-cell stage with zebrafish foxd3 (25 pg) or Xenopus ActivinΒB (25 pg) mRNA and analyzed at the shield stage (6 hpf). (A–F) Live embryos (lateral views, dorsal right) showing the shield and blastoderm structure in uninjected (A, B), foxd3-injected (C, E), and Activin-injected (D, F) embryos. In situ hybridization showing expression of cyclops (G–L), chordin (M–R), goosecoid (S–X), and no tail (Y–D′) (dorsal views).
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Reprinted from Developmental Biology, 342(1), Chang, L.L., and Kessler, D.S., Foxd3 is an Essential Nodal-Dependent Regulator of Zebrafish Dorsal Mesoderm Development, 39-50, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.