ZFIN Image: Phelps et al., 2009, Fig. 7

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Figure Caption

Fig. 7 JNK1 Activation Is Coincident with Nuclear Accumulation of β-Catenin in Human Tumor Samples

FFPE human-matched grossly uninvolved and adenoma samples obtained from FAP patients and unmatched sporadic carcinomas were stained to indicate DNA (magenta) and (A) CtBP (green), (B) β-catenin^* (green), or (C) phospho-cJun (green) as an indicator of JNK activity. Overall, 20 patients matched grossly uninvolved, and adenoma or unmatched carcinoma tissue samples were stained. Shown are two representative samples. All images were captured using the same exposure, and overlapping expression is shown in white.

^*Note: A section from each of the β-catenin-stained adenomas was enlarged to the right. Each antibody was evaluated using serial sections. Scale bar, 5 μm.

Acknowledgments

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Reprinted from Cell, 137(4), Phelps, R.A., Chidester, S., Dehghanizadeh, S., Phelps, J., Sandoval, I.T., Rai, K., Broadbent, T., Sarkar, S., Burt, R.W., and Jones, D.A., A two-step model for colon adenoma initiation and progression caused by APC loss, 623-634, Copyright (2009) with permission from Elsevier. Full text @ Cell