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Fig. S5 Accumulation of PrPs at Cell Contacts Correlates with Increased Levels of Tyrosine Phosphorylation in Drosophila S2 Cells
(A–E) Accumulation of mouse DsRed-monomer-PrP (m PrP) and zebrafish EGFP- and DsRed-monomer-PrP-2 (zf PrP-2) at S2 cell contacts colocalizes with anti-phosphoSrc (α-pSrc, [A]) and anti-phosphotyrosine immunostaining (α-pTyr, [B–E], arrowheads), indicating recruitment and activation of Src tyrosine kinases.
(F) A control mouse DsRed monomer-PrP lacking the PrP core does not cause this effect.
Scale bars indicate 5 μm.
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