ZFIN Image: Aman et al., 2008, Fig. 6

Image

Figure Caption

Fig. 6 Localized Wnt/β-Catenin Signaling Is Necessary for Asymmetric Expression of Chemokine Receptors

(A and B) In 36 hpf WT embryos, (A) cxcr4b is restricted to the leading zone, and (B) cxcr7b is restricted to the trailing zone of the migrating primordium.

(C–F) Expanded Wnt/β-catenin signaling in apc^mcr mutants and SU5402-treated embryos leads to (C and E) expansion of cxcr4b and (D and F) loss of cxcr7b.

(G) cxcr4b expression is not affected by a loss of Wnt/β-catenin signaling.

(H) Loss of Wnt/β-catenin signaling leads to expansion of cxcr7b into the leading zone of the primordium. The scale bar is equal to 40 μM.

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Acknowledgments

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Reprinted from Developmental Cell, 15(5), Aman, A., and Piotrowski, T., Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression, 749-761, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell