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Fig. 3
Mutations that confer protection against neomycin exposure.
Larvae are labeled with DASPEI after 30 min exposure to 200 μM neomycin and 1 hr recovery in normal media. (A) Wildtype animal shows retention of hair cells in neuromasts after mock-treatment. (B) Wildtype animal shows loss of hair cells after aminoglycoside treatment. (C) persephone mutant animal shows robust protection of neuromasts against neomycin treatment. No morphological defects are observed. (D) sentinel mutant animal shows protection, along with sinusoidal body curvature. Bar = 200 μm.
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