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Fig. 1 Defective adult pigment pattern but normal embryonic/early larval pigment pattern of picasso mutants. (A) Wild-type adult pigment pattern of picasso heterozygote. (B) Defective pigment pattern of picasso homozygote. (C,D) Pigment patterns of wild-type and mutant siblings were indistinguishable at 5 dpf. (E-H) Repeated images of wild-type (picasso/+) larvae revealed normal development of initially dispersed metamorphic melanophores that organized into stripes (arrow, E), as well as metamorphic melanophores that developed already at sites of stripe formation. (I-L) picasso mutant larvae develop very few metamorphic melanophores (arrow, L), and instead many embryonic/early larval melanophores (arrowhead, K) persisted into the adult. (E,I) 17 dpf. (F,J) 23 dpf. (G,K) 31 dpf. (H,L) 40 dpf.