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Fig. 4 apoE gene expression in the head region at early larval stage of zebrafish. Ventral (A) and ventro-lateral (B) views of an early larva (4 days of development), focusing on the head region. ApoE transcripts accumulate in cells surrounding the olfactory placodes (op), in branchial arches (ba), and in cells of the inner nuclear layer (inl) of the retina. pf, pectoral fin. (C) Transverse optical cross-section of the head of an early larva at the eye level. Expression of the apoE gene is observed in the retina, in some cells of the forebrain (fb), and in cells surrounding the mouth opening (m). le, lens. (D) Dorsal view of the head region showing the expression of apoE gene in a limited number of cells located both in the hindbrain (hb) and in the tectal part of the midbrain (mb). Early larvae were mounted in Permount and viewed with differential interference contrast optics. (Bar = 50 μm.)