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Fig. 4 ndrg4 morphant phenotypes. Lateral views at 48 hpf. (A, B) The overall morphology of an uninjected (A) and ndrg4-MO2-injected (B) embryos. Compared to its sibling (C), ndrg4-MO2 injected embryo (D) displays pericardial edema, dilated atrium, unlooped, stretched heart and head defects (smaller eyes and prominent edema in the hindbrain). (E) Co-injection of ndrg4 mRNA with ndrg4-MO2 significantly rescued the cardiac, eye and brain phenotype induced by ndrg4 inhibition.
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Reprinted from Developmental Biology, 317(2), Qu, X., Jia, H., Garrity, D.M., Tompkins, K., Batts, L., Appel, B., Zhong, T.P., and Baldwin, H.S., ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish, 486-496, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.