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Fig. S1 Alignment of amino acid sequence of human and zebrafish atp7a Sequence alignment reveals 64.5% identity with marked conservation of CPC copper transport domain (underlined in black), all 6 MXCXXC copper-binding motifs (underlined in red), the invariant aspartate (underlined in blue) and the conserved SEHPL sequence required for trafficking (underlined in green).
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Reprinted from Cell Metabolism, 4(2), Mendelsohn, B.A., Yin, C., Johnson, S.L., Wilm, T.P., Solnica-Krezel, L., and Gitlin, J.D., Atp7a determines a hierarchy of copper metabolism essential for notochord development, 155-162, Copyright (2006) with permission from Elsevier. Full text @ Cell Metab.