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Giudicelli et al., 2007 - Setting the Tempo in Development: An Investigation of the Zebrafish Somite Clock Mechanism

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Fig. 1 Mapping of Temporal Oscillations into a Spatial Wave Pattern during Somite Segmentation, and a Model of the Oscillator Mechanism (A) The expression pattern of the oscillating gene deltaC in a zebrafish embryo at the ten-somite stage. (B) In each cell of the presomitic mesoderm, it is proposed that a her1 or her7 autoinhibition negative feedback loop generates oscillations. (C) Communication via the Delta-Notch pathway is proposed to keep oscillations in adjacent cells synchronized. The oscillations depend critically on the delays (T_m, T_p, T_md, and T_pd) in the feedback loops. (A–C) are slightly modified from [25].

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.