IMAGE

Fig. 5

ID

ZDB-IMAGE-070802-16

Genes

ddx4

Publication

Schlueter et al., 2007 - Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival

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Figures for Schlueter et al., 2007

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Figure Caption

Fig. 5 Ectopic PGCs undergo apoptosis. (A) Vasa immunostaining and (B) TUNEL analysis of ectopic PGCs in dorsal trunk of igf1rb-MO-injected embryo; (C; merged image) colocalization of Vasa-positive (arrows) and TUNEL-positive (arrowheads) cells confirms DNA fragmentation in ectopic PGCs. (D) Vasa-positive but (E) TUNEL-negative PGCs in genital ridge (circled) of igf1rb-MO-injected embryo; images merged in panel F. An absence of DNA fragmentation in genital ridge PGCs confirms survival of the subpopulation of PGCs that successfully migrate to the genital ridge. Anterior is to the left in all images; magnification, 200 x.

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Reprinted from Developmental Biology, 305(1), Schlueter, P.J., Sang, X., Duan, C., and Wood, A.W., Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival, 377-387, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.