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Fig. 5 Figure 5. Dependence of ext1a and ext1c expression on Sonic hedgehog (Shh) signaling. A-F: Dorsal views of 14-somite stage embryos with anterior to the left. Expression of ext1a (A-C) and ext1c (D-F), respectively. A,B,D,E: In smu mutant embryos, expression of ext1a (A) and ext1c (D) is greatly reduced compared with wild-type (wt) embryos (B,E). C,F: Overexpression of shh results in an expansion of the somitic expression domains of ext1a (C) and ext1c (F, compare white brackets in B,C and E,F). Black lines indicate somite borders in (A-C).
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