ZFIN Image: Hagos et al., 2007, Fig. 9

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Figure Caption

Fig. 9 Cell fate specification is accelerated when Nodal levels are increased. Embryos were injected with sqt mRNA at the 1–4 cell stage and treated with DMSO (A1-C1) or SB-431542 at various time points (A2-C7). Sqt induces ubiquitous expression of gsc and sox17 (B1, C1) but not flh (A1). (A2-C2) SB-431542 treatment at MBT blocks expression of each of these markers. flh is strongly expressed in embryos treated at 3.7 h (A3), but fades at later time points (A4-7). gsc expression is first detected in embryos treated at 3.7 h (B3), and expands at later time points (B4-7). sox17 expressing cells are first detected when embryos are treated at 4.3 h (C4), and expands at later time points (C5-7). Animal pole views at 10 h.

Acknowledgments

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