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Fig. 5 Epiboly defect is Nodal-independent. All views are lateral; the mutant phenotype is indicated in upper right corner; the injected construct is indicated in lower left corner. A,B: At 50% epiboly (5.25 hours postfertilization [hpf]). C,D: At sphere stage (4 hpf). A: Embryo injected with eomes-eng; the blastoderm has failed to thin. B: Embryo injected with Mtx2-MO1; the blastoderm has failed to thin. C: mtx2 expression in an uninjected embryo. D: Ectopic mtx2 expression (arrowhead) in an eomes-VP-injected (into a single cell at the eight-cell stage) embryo.
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